Analysis of genomic patchiness of Haemophilus influenzae and Saccharomyces cerevisiae chromosomes
Year: 1996
Authors: Lio P., Politi A., Ruffo S., Buiatti M.
Autors Affiliation: CRC Human Genetic Department, Princess Anne Hospital, University of Southampton, Southampton, U.K.; Istituto Nazionale di Ottica, Largo E. Fermi 6, 50125 Firenze, Italy; Dipartimento di Energetica, Università di Firenze, Via S. Marta 3, 50139 Firenze, Italy; Dipartimento di Biologia Animale e Genetica, Università di Firenze, Via Romana 17, 50125 Firenze, Italy; INFN e INFM, Firenze, Italy
Abstract: We have analysed some aspects of the primary structure of the chromosome of the prokaryote Haemophilus influenzae and of the eukaryote Saccharomyces cerevisiae that share the same G + C content. In particular, we have investigated genomic patchiness over the gene size level (10 Kb) and that patchiness due to long homogeneous tracts. Long polypurine and polypyrmidine tracts that are largely over-represented in S. cerevisiae chromosomes and under-represented in H. influenzae, are responsible for a large fraction of long correlation signals. Generating mechanisms of long homogeneous tracts are DNA replication slippage and duplication events that appear to be linked processes driving chromosome primary structure evolution. (C) 1996 Academic Press Limited
Journal/Review: JOURNAL OF THEORETICAL BIOLOGY
Volume: 183 (4) Pages from: 455 to: 469
KeyWords: STEPWISE MUTATION MODEL; MEIOTIC RECOMBINATION; NUCLEOTIDE-SEQUENCES; CODON REITERATION; POLYPURINE TRACTDOI: 10.1006/jtbi.1996.0235Citations: 11data from “WEB OF SCIENCE” (of Thomson Reuters) are update at: 2024-04-28References taken from IsiWeb of Knowledge: (subscribers only)Connecting to view paper tab on IsiWeb: Click hereConnecting to view citations from IsiWeb: Click here