Depth dependence of estimated optical properties of a scattering inclusion by time-resolved contrast functions
Year: 2008
Authors: Esposito R., De Nicola S., Brambilla M., Pifferi A., Spinelli L., Lepore M.
Autors Affiliation: Dipartimento Scienze Fisiche, Università di Napoli “Federico II”, Italy;
Istituto di Cibernetica del C.N.R “E. Caianiello”, compr. A. Olivetti, Via Campi Flegrei 34, 80078 Pozzuoli, Italy;
IIT, ULTRAS–INFM–CNR and IFN–CNR, Politecnico di Milano–Dipartimento di Fisica,
Piazza Leonardo da Vinci 32, 20133 Milan, Italy;
Dipartimento di Medicina Sperimentale, Seconda Universita di Napoli, CNISM, Italy
Abstract: In this study we have theoretically and experimentally investigated the behavior of first order approximation contrast function when purely scattering inhomogeneities located at different depths inside a turbid thick slab are considered. Results of model predictions have been compared with Finite element method simulations and tested on phantoms. To this aim, we have developed for the first time to our knowledge a fitting algorithm for estimating both the scattering perturbation parameter and the shift of the inhomogeneity from the middle plane, allowing one to reduce the uncertainties due to depth. This is important for optical mammography because effects of the depth can cause uncertainties in the derived tumor optical properties that are above 20% and the scattering properties of tumors differ from those of the sourrounding healthy tissue by a comparable extent. (C) 2008 Optical Society of America
Journal/Review: OPTICS EXPRESS
Volume: 16 (22) Pages from: 17667 to: 17681
KeyWords: TURBID MEDIA; DIFFUSION; SCATTERING; OPTICAL PROPERTIES; ABSORPTIONDOI: 10.1364/OE.16.017667Citations: 3data from “WEB OF SCIENCE” (of Thomson Reuters) are update at: 2024-04-28References taken from IsiWeb of Knowledge: (subscribers only)Connecting to view paper tab on IsiWeb: Click hereConnecting to view citations from IsiWeb: Click here