Characterization of a bioinspired elastin-polypropylene fumarate material for vascular prostheses applications

Year: 2013

Authors: Scaglione S., Barenghi R., Beke S., Ceseracciu L., Romano I., Sbrana F., Stagnaro P., Brandi F., Vassalli M.

Autors Affiliation: IEIIT, National Research Council (CNR), Genova, Italy;
Nanophysics Dept., Istituto Italiano di Tecnologia (IIT), Genova, Italy;
IBF, National Research Council (CNR), Genova, Italy;
ISMAC, National Research Council (CNR), Genova, Italy

Abstract: Vascular prostheses are widely used devices fundamental to avoid the effect of life-threatening diseases and defects. Besides a long experience in the fabrication of biomaterials for vascular applications, many issues still remain unattended. In particular, obtaining a bio-resorbable and bio-active scaffold is a challenge of paramount importance. We present a novel application in which a promising biodegradable polymer, poly-propylene fumarate (PPF), is printed using three dimensional laser-induced cross-linking micromachining device. To enhance the biological role of the scaffold, a bio-inspired approach was taken, by coating the surface of the PPF with elastin, the main constituent of the innermost layer of natural veins and arteries.

Conference title:

More Information: – The Society of Photo-Optical Instrumentation Engineers (SPIE)
KeyWords: Scaffold; Poly-propylene fumarate; PPF; Vascular prostheses