Brain-wide charting of neuronal activation maps with cellular resolution
Authors: Silvestri L., Rudinskiy N., Paciscopi M., Müllenbroich M.C., Costantini I., Sacconi L., Frasconi P., Hyman B.T., Pavone F.S.
Autors Affiliation: National Institute of Optics, National Research Council, Via Nello Carrara, 1, Sesto Fiorentino (FI), 50019, Italy; European Laboratory for Non-linear Spectroscopy (LENS), University of Florence, Via Nello Carrara, 1, Sesto Fiorentino (FI), 50019, Italy; Alzheimer Disease Research Center, Massachussets General Hospital, 114 16th Street, Charlestown, MA 02129, United States; Department of Information Engineering (DINFO), University of Florence, Via di Santa Marta, 3, Firenze, 50139, Italy; Department of Physics and Astronomy, University of Florence, Via G. Sansone, 1, Sesto Fiorentino (FI), 50019, Italy; International Center of Computational Neurophotonics (ICON), Via Nello Carrara, 1, Sesto Fiorentino (FI), 50019, Italy
Abstract: Charting neuronal activation with single-cell resolution on a brain-wide scale is a crucial step towards a comprehensive view of brain function. Here we present a method to localize individual activated neurons across entire mouse brains.
KeyWords: Chemical activation; Mobile security, Brain functions; Cellular resolution; Mouse brain; Neuronal activation; Single cell resolution, NeuronsDOI: 10.1364/BRAIN.2015.BrM3B.6