Hyperspectral analysis applied to micro-Brillouin maps of amyloid-beta plaques in Alzheimer’s disease brains

Year: 2018

Authors: Palombo F.; Masia F.; Mattana S.; Tamagnini F.; Borri P.; Langbein W.; Fioretto D.

Autors Affiliation: University of Exeter, School of Physics and Astronomy, Exeter, EX4 4QL, United Kingdom; Cardiff University, School of Physics and Astronomy, Cardiff, CF24 3AA, United Kingdom; CNR-National Institute of Optics, Firenze, I-50125, Italy; University of Reading, School of Pharmacy, Reading, RG6 6LA, United Kingdom; Cardiff University, School of Biosciences, Cardiff, CF10 3AX, United Kingdom; University of Perugia, Department of Physics and Geology, Perugia, I-06100, Italy

Abstract: A recent investigation on the architecture and chemical composition of amyloid-ß (Aß) plaques in ex vivo histological sections of an Aß-overexpressing transgenic mouse hippocampus has shed light on the infrared light signature of cell-activation related biomarkers of Alzheimer

Journal/Review: ANALYST

Volume: 143 (24)      Pages from: 6095  to: 6102

More Information: This work was generously supported by the Wellcome Trust Institutional Strategic Support Award (WT105618MA). The animals were supplied by GlaxoSmithKline, as part of the European Union PharmacogIMI consortium.
KeyWords: Algorithms; Alzheimer Disease; Amyloid beta-Peptides; Animals; Elasticity; Hippocampus; Male; Mice, Transgenic; Microscopy, Confocal; Plaque, Amyloid; Viscosity
DOI: 10.1039/c8an01291a

Citations: 17
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