LESM: a laser-driven sub-MeV electron source delivering ultra-high dose rate on thin biological samples
Authors: Labate L., Andreassi MG., Baffigi F., Bizzarri R., Borghini A., Bussolino GC., Fulgentini L., Ghetti F., Giulietti A., Koster P., Lamia D., Levato T., Oishi Y., Pulignani S., Russo G., Sgarbossa A., Gizzi LA.
Autors Affiliation: Istituto Nazionale di Ottica, Consiglio Nazionale delle Ricerche, Pisa, Italy
Istituto di Fisiologia Clinica, Consiglio Nazionale delle Ricerche, Pisa, Italy
NEST, Istituto Nanoscienze, Consiglio Nazionale delle Ricerche and Scuola Normale Superiore, Pisa, Italy
Istituto di Bioimmagini e Fisiologia Molecolare, Consiglio Nazionale delle Ricerche—LATO,
ELI-Beamlines, Institute of Physics of the Czech Academy of Science, Prague, Czech Republic
Central Research Institute of Electric Power Industry, Kanagawa, Japan
Abstract: We present a laser-driven source of electron bunches with average energy 260 keV and picosecond duration, which has been setup for radiobiological tests covering the previously untested sub-MeV energy range. Each bunch combines high charge with short duration and sub-millimeter range into a record instantaneous dose rate, as high as 10(9) Gy s(-1). The source can be operated at 10 Hz and its average dose rate is 35 mGy s(-1). Both the high instantaneous dose rate and high level of relative biological effectiveness, attached to sub-MeV electrons, make this source very attractive for studies of ultrafast radiobiology on thin cell samples. The source reliability, in terms of shot-to-shot stability of features such as mean energy, bunch charge and transverse beam profile, is discussed, along with a dosimetric characterization. Finally, a few preliminary biological tests performed with this source are presented.
Journal/Review: JOURNAL OF PHYSICS D-APPLIED PHYSICS
Volume: 49 (27) Pages from: 275401-1 to: 275401-9
KeyWords: Sub-MeV electron sources; Laser-driven electron accelerators; Ultrahigh dose rate; Cell radiation; RadiobioplogyDOI: 10.1088/0022-3727/49/27/275401Citations: 6data from “WEB OF SCIENCE” (of Thomson Reuters) are update at: 2021-06-20References taken from IsiWeb of Knowledge: (subscribers only)Connecting to view paper tab on IsiWeb: Click hereConnecting to view citations from IsiWeb: Click here