Diagnostic Tools for Lab-on-Chip Applications Based on Coherent Imaging Microscopy

Year: 2015

Authors: Merola F., Memmolo P., Miccio L., Bianco V., Paturzo M., Ferraro P.

Autors Affiliation: CNR, I-80078 Naples, Italy

Abstract: Today, fast and accurate diagnosis through portable and cheap devices is in high demand for the general healthcare. Lab-on-chips (LoCs) have undergone a great growth in this direction, supported by optical imaging techniques more and more refined. Here we present recent progresses in developing imaging tools based on coherent imaging microscopy that can be very useful when applied into biomicrofluidics. In some cases, the optical tweezers (OT) technique is combined with digital holography (DH), thus offering the possibility to manipulate, analyze, and measure fundamental parameters of different kinds of cells. This approach can open the route for rapid and high-throughput analysis in label-free microfluidic devices and for prognostic based on cell examination, thus allowing advancements in biomedical science.


Volume: 103 (2)      Pages from: 192  to: 204

More Information: This work was supported by Progetto Bandiera “La Fabbrica del Futuro” in the framework of the funded project “Plastic lab-on-chips for the optical manipulation of single cells” (PLUS); and by Progetto “Smart Cities”-Acquasystem: “Procedure e tecnologie innovative per una gestione pianificata ed integrata delle risorse idriche, l
KeyWords: Biophotonics; diagnostics; fibroblasts; healthcare; lab-on-a-chip
DOI: 10.1109/JPROC.2014.2375374

Citations: 82
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