Detection of colorectal cancer biomarkers in the presence of interfering gases

Year: 2015

Authors: Zonta G., Anania G., Fabbri B., Gaiardo A., Gherardi S., Giberti A., Guidi V., Landini N., Malagu C.

Autors Affiliation: Univ Ferrara, Dept Phys & Earth Sci, I-44122 Ferrara, Italy;‎ MIST ER Scrl, I-40129 Bologna, Italy;‎ CNR, INO, I-50124 Florence, Italy;‎ Univ Ferrara, Dept Morphol Surg & Expt Med, I-44121 Ferrara, Italy; Bruno Kessler Fdn, MNF, I-38123 Trento, Italy

Abstract: Medical studies have shown that tumor growth is accompanied by protein changes that may lead to the peroxidation of the cell membrane, with consequent emission of volatile organic compounds (VOCs). VOCs can be detected through breath or intestinal gases and are biomarkers for colorectal cancer (CRC). The analysis of VOCs represents a non-invasive and potentially inexpensive pre-screening technique. An array of chemoresistive gas sensors, based on screen-printed Metal OXide (MOX) semiconducting films, has been selected to identify gaseous compounds of oncological interest, i.e. benzene, 1-iodo-nonane and decanal, from the main interferers that can be found in the intestine. MOX sensors are able to detect concentrations down to about 10th ppb, as experimentally proven in previous works, so they can identify very slight differences in concentration among gas mixtures. In this work it has been proven that the array used is able to identify tumor markers singularly and in combination with other gases both in wet and dry conditions. Moreover, the sensors chosen can discriminate target VOCs from interferers even at low concentrations. (C) 2015 Elsevier B.V. All rights reserved.


Volume: 218      Pages from: 289  to: 295

KeyWords: VOC; Colorectal cancer; Sensor; Benzene; 1-Iodo-nonane; Decanal
DOI: 10.1016/j.snb.2015.04.080

Citations: 19
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