Towards a clearer view of sympathetic innervation of cardiac and skeletal muscles
Authors: Di Bona A., Vita V., Costantini I., Zaglia T.
Autors Affiliation: Univ Padua, Dept Cardiac Thorac & Vasc Sci & Publ Hlth, Via Giustiniani 2, I-35128 Padua, Italy; Veneto Inst Mol Med, Via Orus 2, I-35129 Padua, Italy; Univ Florence, Natl Inst Opt, Natl Res Council, Via Nello Carrara 1, I-50019 Florence, Italy; Univ Florence, European Lab Nonlinear Spect, Via Nello Carrara 1, I-50019 Florence, Italy; Univ Padua, Dept Biomed Sci, Via Ugo Bassi 58-B, I-35122 Padua, Italy
Abstract: It is well appreciated that autonomic neurons have a central role in the homeostatic regulation of organs and systems and participate to the pathogenesis of several disease conditions. As such, the function and signalling pathways activated by sympathetic neurons (SNs) in different cell types and organs have become a matter of intense investigation throughout the years of modern biomedical research. This review is focused on the methods used to address sympathetic innervation of cardiac and skeletal muscles which, quite surprisingly, has remained incompletely understood, mainly due to the technical limitations of the traditional methodologies. The current review provides a summary of the existing literature and, putting together the results obtained with different methodological approaches, provides a comprehensive view of the complexity of the SN network in striated muscles. (C) 2019 Elsevier Ltd. All rights reserved.
Journal/Review: PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
Volume: 154 Pages from: 80 to: 93
KeyWords: Sympathetic neurons; Heart; Skeletal muscle; Electron microscopy; Immunofluorescence; Multiphoton microscopeDOI: 10.1016/j.pbiomolbio.2019.07.003Citations: 3data from “WEB OF SCIENCE” (of Thomson Reuters) are update at: 2021-02-28References taken from IsiWeb of Knowledge: (subscribers only)Connecting to view paper tab on IsiWeb: Click hereConnecting to view citations from IsiWeb: Click here