Experimental study of the mechanisms leading to the formation of glistenings in intraocular lenses by Raman spectroscopy
Authors: Rusciano G., Capaccio A., Pesce G., Sasso A.
Autors Affiliation: Univ Naples Federico II, Compl Univ MS Angelo, Dept Phys E Pancini, Via Cinthia, I-80126 Naples, Italy; Natl Inst Opt INO CNR, Comprensorio Olivetti Via Campi Flegrei 34, I-80078 Pozzuoli, NA, Italy
Abstract: The phenomenon of glistenings, often appearing in intraocular lenses (IOLs) of patients after some time from the surgical operation, is potentially able to induce a poor quality of vision and, therefore, frustrate IOL implantation itself. In this paper, we combine optical microscopy with micro-Raman spectroscopy to get a deeper insight on the mechanism ruling, at microscopic scale, glistening formation. In particular, we have analyzed two types of IOLs, characterized by a different internal hydrophobicity but a similar polymer hydration coefficient. Raman imaging of single microvacuoles reveals that water creeps into the polymeric network, which traps water. Finally, applying the Principal Component Analysis (PCA) to Raman data, we provide information on the probable mechanism leading to water trapping in the two kinds of analyzed IOLs. (C) 2019 Optical Society of America under the terms of the OSA Open Access Publishing Agreement
Journal/Review: BIOMEDICAL OPTICS EXPRESS
Volume: 10 (4) Pages from: 1870 to: 1881
KeyWords: SOFT CONTACT-LENSES; POLY(METHYL METHACRYLATE); MOLECULAR-STRUCTURE; VISUAL FUNCTION; LIGHT SCATTER; WATER; SPECTRA; POLYMERIZATION; ABSORPTION; VIBRATIONSDOI: 10.1364/BOE.10.001870Citations: 1data from “WEB OF SCIENCE” (of Thomson Reuters) are update at: 2020-07-05References taken from IsiWeb of Knowledge: (subscribers only)Connecting to view paper tab on IsiWeb: Click hereConnecting to view citations from IsiWeb: Click here