Blue LED light modulates inflammatory infiltrate and improves the healing of superficial wounds
Authors: Magni G., Tatini F., Bacci S., Paroli G., De Siena G., Cicchi R., Pavone FS., Pini R., Rossi F.
Autors Affiliation: Institute of Applied Physics, National Research Council (IFAC-CNR), Sesto Fiorentino, Italy
Department of Biology, University of Florence, Florence, Italy
National Institute of Optics, National Research Council (INO-CNR), Florence, Italy
European Laboratory for Non-Linear Spectroscopy (LENS), University of Florence, Sesto Fiorentino, Italy
Department of Physics, University of Florence, Sesto Fiorentino, Italy
Abstract: Previously published studies have evidenced that the blue LED light (420 nm) irradiation of superficial wounds is capable of inducing
hemostasis by means of a photo-thermo-coagulation process: Light absorption by means of hemoglobin triggers a local increase
in temperature, thus leading to a coagulative effect. During the follow-up studies, we observed a better organization of the collagen
in the wound bed and a faster healing process, one that could be ascribed to photo effects rather than to a photo thermal one, for example,
to photochemical effects. In addition to hemoglobin, other macromolecules, such as cytochromes, absorb blue light. After irradiation,
these ubiquitous cellular components are able to trigger one or more intracellular pathways that can modulate the healing process.
KeyWords: blue light, photo-bio-modulation, superficial wounds, wound healing