Costantini Irene

Professional Profile: (Associated)
Activity field: Research
Main office/laboratory: Sezione Sesto Fiorentino – LENS
Office phone number: 055 4572514
Laboratory phone number: 055 4572018
E-mail:
OrcidID: 0000-0002-8464-7324ScopusID: 55794261400
Primary activity: IC research activity is focused on the three-dimensional reconstruction of intact neuronal networks and cardiac conduction system, with cellular resolution, of whole mouse brain and heart and human brain samples using light sheet microscopy with two-photon fluorescence microscopy. To this aim, she is developing new clearing methods to obtain transparent samples that are macromolecule-permeable and compatible with fluorescence immunostaining.

Main experiences acquired: Biology: comparative anatomy and cytology. Sample preparation with tissue clearing, immunohistochemistry and immunofluorescence techniques. Biophysics (optics): analysis of the sample with confocal fluorescence microscopy, two photons, sheet of light and transmission electron microscopy. Translational and genetic biology (study of neuroanatomical alterations related to mutations of various pathways: e.g. mTOR, management of transgenic mice line), molecular biology: extraction of DNA from murine tissue, PCR, gel electrophoresis, microsurgery on transgenic animals.

Research Groups:
Neuronal imaging

Others Funded Projects in which he/she participates:
Human Brain Project – SGA2
Human Brain Project – SGA3

Publications, Research Results, now, in INO’s database are: 38
  –   Papers JCR/ISI Journals, are: 18
  –   Books or Chapters, are: 0
  –   Papers in Journals not indexed JCR/ISI, are: 0
  –   Conference proceedings, are: 19
  –   Abstract, are: 1

Bibliometric indices are calculated USING ONLY THE INO DATABASE and the number of citations from “WEB OF SCIENCE” (of Thomson Reuters) is updated at 2021-10-17
  –   maximum number of citations for an article: 136
  –   maximum impact factor (IF) for a journal when an article is published: 5.266
  –   H-INDEX: 9   G-INDEX: 16   HC-INDEX (contemporary): 8 
  –   List of TopTen papers in citations  –   List of TopTen journals in Impact Factor

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