The communication published in Angewandte Chemie (IF 11.994) by research group of Raffaella Fontana has been selected as a HOT PAPER for its importance in a rapidly evolving field of high current interest. In collaboration with the Czech Academy of Science, the researchers propose the methodology based on advanced techniques of data-processing to analyze inhomogeneous datasets. This approach is demonstrated on two paintings by Titian and Manet examined in different contexts, times and partially different techniques. https://doi.org/10.1002/anie.201800624