IndietroAutore: Costantini Irene 1) Universal autofocus for quantitative volumetric microscopy of whole mouse brains in NATURE METHODSDi: Silvestri L., Mullenbroich MC., Costantini I., Di Giovanna AP., Mazzamuto G., Franceschini A., Kutra D., Kreshuk A., Checcucci C., Toresano LO., Frasconi P., Sacconi L., Pavone FS. Anno: 2021 (IF.: 47.990 Cit.: 30 DOI: 10.1038/s41592-021-01208-1)
2) Toward a High-Resolution Reconstruction of 3D Nerve Fiber Architectures and Crossings in the Brain Using Light Scattering Measurements and Finite-Difference Time-Domain Simulations in PHYSICAL REVIEW XDi: Menzel M., Axer M., De Raedt H., Costantini I., Silvestri L., Pavone FS., Amunts K., Michielsen K. Anno: 2020 (IF.: 15.762 Cit.: 17 DOI: 10.1103/PhysRevX.10.021002)
3) A cellular resolution atlas of Broca?s area in SCIENCE ADVANCESDi: Costantini I., Morgan L., Yang JR., Balbastre Y., Varadarajan D., Pesce L., Scardigli M., Mazzamuto G., Gavryusev V., Castelli FM., Roffilli M., Silvestri L., Laffey J., Raia S., Varghese M., Wicinski B., Chang SB., Chen IA., Wang H., Cordero D., Vera M., Nolan J., Nestor K., Mora J., Iglesias JE., Pallares EG., Evancic K., Augustinack JC., Fogarty M., Dalca AV., Frosch MP., Magnain C., Frost R., van der Kouwe A., Chen SC., Boas DA., Pavone FS., Fischl B., Hof PR. Anno: 2023 (IF.: 11.700 Cit.: 4 DOI: 10.1126/sciadv.adg3844)
4) Brain-wide neuron quantification toolkit reveals strong sexual dimorphism in the evolution of fear memory in CELL REPORTSDi: Franceschini A., Mazzamuto G., Checcucci C., Chicchi L., Fanelli D., Costantini I., Passani MB., Silva BA., Pavone FS., Silvestri L. Anno: 2023 (IF.: 7.500 Cit.: 2 DOI: 10.1016/j.celrep.2023.112908)
5) 3D molecular phenotyping of cleared human brain tissues with light-sheet fluorescence microscopy in COMMUNICATIONS BIOLOGYDi: Pesce Luca; Scardigli Marina; Gavryusev Vladislav; Laurino Annunziatina; Mazzamuto Giacomo; Brady Niamh; Sancataldo Giuseppe; Silvestri Ludovico; Destrieux Christophe; Hof Patrick R.; Costantini Irene; Pavone Francesco S. Anno: 2022 (IF.: 5.900 Cit.: 16 DOI: 10.1038/s42003-022-03390-0)
6) Neurophotonic tools for microscopic measurements and manipulation: status report in NEUROPHOTONICSDi: Abdelfattah AS., Ahuja S., Akkin T., Allu SR., Brake J., Boas DA., Buckley EM., Campbell RE., Chen AI., Cheng XJ., Cizmbr T., Costantini I., De Vittorio M., Devor A., Doran PR., El Khatib M., Emiliani V., Fomin-Thunemann N., Fainman Y., Fernandez-Alfonso T., Ferri CGL., Gilad A., Han X., Harris A., Hillman EMC., Hochgeschwender U., Holt MG., Ji N., Kiliz K., Lake EMR., Li L., Li TQ., Mdchler P., Miller EW., Mesquita RC., Nadella KMNS., Ndgerl UV., Nasu Y., Nimmerjahn A., Ondrbckovb P., Pavone FS., Campos CP., Peterka DS., Pisano F., Pisanello F., Puppo F., Sabatini BL., Sadegh S., Sakadzic S., Shoham S., Shroff SN., Silver RA., Sims RR., Smith SL., Srinivasan VJ., Thunemann M., Tian L., Tian L., Troxler T., Valera A., Vaziri A., Vinogradov SA., Vitale F., Wang LV., Uhlnrovb H., Xu C., Yang CHE., Yang MH., Yellen G., Yizhar O., Zhao YX. Anno: 2022 (IF.: 5.300 Cit.: 19 DOI: 10.1117/1.NPh.9.S1.013001)
7) A promoter polymorphism in human interleukin-32 modulates its expression and influences the risk and the outcome of epithelial cell-derived thyroid carcinoma in CARCINOGENESISDi: Plantinga T.S., Costantini I., Heinhuis B., Huijbers A., Semango G., Kusters B., Netea M.G., Hermus A.R.M.M., Smit J.W.A., Dinarello C.A., Joosten L.A.B., Netea-Maier R.T. Anno: 2013 (IF.: 5.266 Cit.: 33 DOI: 10.1093/carcin/bgt092)
8) A versatile clearing agent for multi-modal brain imaging in SCIENTIFIC REPORTSDi: Costantini I., Ghobril J.P., Di Giovanna A.P., Allegra Mascaro A. L., Silvestri L., Müllenbroich M.C., Onofri L., Conti V., Vanzi F., Sacconi L., Guerrini R., Markram H., Iannello G., Pavone F.S. Anno: 2015 (IF.: 5.228 Cit.: 189 DOI: 10.1038/srep09808)
9) A versatile clearing agent for multi modal brain imaging in SCIENTIFIC REPORTSDi: Costantini I., Ghobril JP, Di Giovanna AP, Allegra Mascaro AL, Silvestri L, Mllenbroich MC, Onofri L, Conti V, Vanzi F, Sacconi L, Guerrini R, Markram H, Iannello G, Pavone FS Anno: 2015 (IF.: 5.228 DOI: 10.1038/srep09808)
10) Autofluorescence enhancement for label‑free imaging of myelinated fibers in mammalian brains in SCIENTIFIC REPORTSDi: Costantini I., Baria E., Sorelli M., Matuschke F., Giardini F., Menzel M., Mazzamuto G., Silvestri L., Cicchi R., Amunts K., Axer M., Pavone F.S. Anno: 2021 (IF.: 4.996 Cit.: 19 DOI: 10.1038/s41598-021-86092-7)
11) A Guide to Perform 3D Histology of Biological Tissues with Fluorescence Microscopy in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCESDi: Laurino A., Franceschini A., Pesce L., Cinci L., Montalbano A., Mazzamuto G., Sancataldo G., Nesi G., Costantini I., Silvestri L., Pavone FS. Anno: 2023 (IF.: 4.900 Cit.: 4 DOI: 10.3390/ijms24076747)
12) Exploring the human cerebral cortex using confocal microscopy in PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGYDi: Pesce Luca; Laurino Annunziatina; Scardigli Marina; Yang Jiarui; Boas David A.; Hof Patrick R.; Destrieux Christophe; Costantini Irene; Pavone Francesco Saverio Anno: 2021 (IF.: 4.799 Cit.: 12 DOI: 10.1016/j.pbiomolbio.2021.09.001)
13) Quantification of Myocyte Disarray in Human Cardiac Tissue in FRONTIERS IN PHYSIOLOGYDi: Giardini F., Lazzeri E., Vitale G., Ferrantini C., Costantini I., Pavone FS., Poggesi C., Bocchi L., Sacconi L. Anno: 2021 (IF.: 4.755 Cit.: 5 DOI: 10.3389/fphys.2021.750364)
14) Dissecting Neuronal Activation on a Brain-Wide Scale With Immediate Early Genes in FRONTIERS IN NEUROSCIENCEDi: Franceschini A., Costantini I., Pavone FS., Silvestri L. Anno: 2020 (IF.: 4.677 Cit.: 26 DOI: 10.3389/fnins.2020.569517)
15) Automated computation of nerve fibre inclinations from 3D polarised light imaging measurements of brain tissue in SCIENTIFIC REPORTSDi: Menzel M., Reuter JA., Graessel D., Costantini I., Amunts K., Axer M. Anno: 2022 (IF.: 4.600 Cit.: 5 DOI: 10.1038/s41598-022-08140-0)
16) Cardiac sympathetic innervation network shapes the myocardium by locally controlling cardiomyocyte size through the cellular proteolytic machinery in JOURNAL OF PHYSIOLOGY-LONDONDi: Pianca N., Di Bona A., Lazzeri E., Costantini I., Franzoso M., Prando V., Armani A., Rizzo S., Fedrigo M., Angelini A., Basso C., Pavone FS., Rubart M., Sacconi L., Zaglia T., Mongillo M. Anno: 2019 (IF.: 4.547 Cit.: 36 DOI: 10.1113/JP276200)
17) 3D imaging and morphometry of the heart capillary system in spontaneously hypertensive rats and normotensive controls in SCIENTIFIC REPORTSDi: Olianti C., Costantini I., Giardini F., Lazzeri E., Crocini C., Ferrantini C., Pavone FS., Camici PG., Sacconi L. Anno: 2020 (IF.: 4.379 Cit.: 17 DOI: 10.1038/s41598-020-71174-9)
18) Whole-Brain Vasculature Reconstruction at the Single Capillary Level in SCIENTIFIC REPORTSDi: Di Giovanna A.P., Tibo A., Silvestri L., Muellenbroich M.C., Costantini I., Allegra Mascaro A.L., Sacconi L., Frasconi P., Pavone F.S. Anno: 2018 (IF.: 4.011 Cit.: 83 DOI: 10.1038/s41598-018-30533-3)
19) Whole-Brain Vasculature Reconstruction at the Single Capillary Level (vol 8, 12573, 2018) in SCIENTIFIC REPORTSDi: Di Giovanna AP., Tibo A., Silvestri L., Mullenbroich MC., Costantini I., Allegra Mascaro AL., Sacconi L., Frasconi P., Pavone FS. Anno: 2019 (IF.: 3.998 DOI: 10.1038/s41598-019-42216-8)
20) Gene polymorphisms in pattern recognition receptors and susceptibility to idiopathic recurrent vulvovaginal candidiasis in FRONTIERS IN MICROBIOLOGYDi: Rosentul D.C., Delsing C.E., Jaeger M., Plantinga T.S., Oosting M., Costantini I., Venselaar H., Joosten L.A.B., van der Meer J.W.M., Dupont B., Kullberg B.-J., Sobel J.D., Netea M.G. Anno: 2014 (IF.: 3.989 DOI: 10.3389/fmicb.2014.00483)
21) In-vivo and ex-vivo optical clearing methods for biological tissues: review in BIOMEDICAL OPTICS EXPRESSDi: Costantini I., Cicchi R., Silvestri L., Vanzi F., Pavone F.S. Anno: 2019 (IF.: 3.921 Cit.: 111 DOI: 10.1364/BOE.10.005251)
22) Fiber enhancement and 3D orientation analysis in label-free two-photon fluorescence microscopy in SCIENTIFIC REPORTSDi: Sorelli Michele; Costantini Irene; Bocchi Leonardo; Axer Markus; Pavone Francesco Saverio; Mazzamuto Giacomo Anno: 2023 (IF.: 3.800 Cit.: 4 DOI: 10.1038/s41598-023-30953-w)
23) Towards a clearer view of sympathetic innervation of cardiac and skeletal muscles in PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGYDi: Di Bona A., Vita V., Costantini I., Zaglia T. Anno: 2020 (IF.: 3.667 Cit.: 18 DOI: 10.1016/j.pbiomolbio.2019.07.003)
24) Improving the characterization of ex vivo human brain optical properties using high numerical aperture optical coherence tomography by spatially constraining the confocal parameters in NEUROPHOTONICSDi: Yang JR., Chen IA., Chang SB., Tang JB., Lee B., Kiliz K., Sunil S., Wang H., Varadarajan D., Magnain C., Chen SC., Costantini I., Pavone F., Fischl B., Boas DA. Anno: 2020 (IF.: 3.593 Cit.: 14 DOI: 10.1117/1.NPh.7.4.045005)
25) Large-scale, cell-resolution volumetric mapping allows layer-specific investigation of human brain cytoarchitecture in BIOMEDICAL OPTICS EXPRESSDi: Costantini I., Mazzamuto G., Roffilli M., Laurino A., Castelli FM., Neri M., Lughi G., Simonetto A., Lazzeri E., Pesce L., Destrieux C., Silvestri L., Conti V., Guerrini R., Pavone FS Anno: 2021 (IF.: 3.562 Cit.: 16 DOI: 10.1364/BOE.415555)
26) Comparison of Different Tissue Clearing Methods for Three-Dimensional Reconstruction of Human Brain Cellular Anatomy Using Advanced Imaging Techniques in FRONTIERS IN NEUROANATOMYDi: Scardigli M., Pesce L., Brady N., Mazzamuto G., Gavryusev V., Silvestri L., Hof PR., Destrieux C., Costantini I., Pavone FS. Anno: 2021 (IF.: 3.543 Cit.: 9 DOI: 10.3389/fnana.2021.752234)
27) Label-free near-infrared reflectance microscopy as a complimentary tool for two-photon fluorescence brain imaging in BIOMEDICAL OPTICS EXPRESSDi: Allegra Mascaro A.L., Costantini I., Margoni E., Iannello G., Bria A., Sacconi L., Pavone F.S. Anno: 2015 (IF.: 3.344 Cit.: 13 DOI: 10.1364/BOE.6.004483)
28) Clearing of fixed tissue: a review from a microscopist´s perspective in JOURNAL OF BIOMEDICAL OPTICSDi: Silvestri L., Costantini I., Sacconi L., Pavone F.S. Anno: 2016 (IF.: 2.530 Cit.: 104 DOI: 10.1117/1.JBO.21.8.081205)
29) Mesoscopic Optical Imaging of Whole Mouse Heart in JOVE-JOURNAL OF VISUALIZED EXPERIMENTSDi: Giardini F., Lazzeri E., Olianti C., Beconi G., Costantini I., Silvestri L., Cerbai E., Pavone FS., Sacconi L. Anno: 2021 (IF.: 1.424 Cit.: 3 DOI: 10.3791/62795)
30) Comprehensive optical and data management infrastructure for high-throughput light-sheet microscopy of whole mouse brains in NEUROPHOTONICSDi: Muellenbroich M.C., Silvestri L., Onofri L., Costantini I., Van’t Hoff M., Sacconi L., Iannello G., Pavone F.S. Anno: 2015 (Cit.: 17 DOI: 10.1117/1.NPh.2.4.041404)
31) Micron-scale Resolution Optical Tomography of Entire Mouse Brains with Confocal Light Sheet Microscopy in JOVE-JOURNAL OF VISUALIZED EXPERIMENTSDi: Silvestri L., Bria A., Costantini I., Sacconi L., Peng H., Iannello G., Pavone F.S. Anno: 2013 (Cit.: 17 DOI: 10.3791/50696)
32) High-fidelity imaging in brain-wide structural studies using light-sheet microscopy in ENEURODi: Müllenbroich M.C., Silvestri L., Di Giovanna A.P., Mazzamuto G., Costantini I., Sacconi L., Pavone F.S. Anno: 2018 (Cit.: 13 DOI: 10.1523/ENEURO.0124-18.2018)
33) Deep learning-based localization algorithms on fluorescence human brain 3D reconstruction: a comparative study using stereology as a reference in SCIENTIFIC REPORTSDi: Checcucci C., Wicinski B., Mazzamuto G., Scardigli M., Ramazzotti J., Brady N., Pavone FS., Hof PR., Costantini I., Frasconi P. Anno: 2024 ( DOI: 10.1038/s41598-024-65092-3)
34) Optical Clearing and Labeling for Light-sheet Fluorescence Microscopy in Large-scale Human Brain Imaging in JOVE-JOURNAL OF VISUALIZED EXPERIMENTSDi: Di Meo D., Ramazzotti J., Scardigli M., Cheli F., Pesce L., Brady N., Mazzamuto G., Costantini I., Pavone FS. Anno: 2024 ( DOI: 10.3791/65960)
35) Three-dimensional analysis of human brain cytoarchitectonics by means of a SWITCH/TDE-combined clearing method in JOURNAL OF THE OPTICAL SOCIETY OF AMERICA B-OPTICAL PHYSICSDi: Costantini I., Mazzamuto G., Laurino A., Lazzari E., Sacconi L., Neri M., Simonetto A., Ruffilli M., Silvestri L., Pavone FS. Anno: 2019 36) 3D human brain digital istopatology in JOURNAL OF THE OPTICAL SOCIETY OF AMERICA B-OPTICAL PHYSICSDi: Costantini I., Mazzamuto G., Silvestri L., Neri M., Roffilli M., Conti V., Guerrini R., Sacconi L., Pavone F.S. Anno: 2018 ( DOI: 10.1364/BRAIN.2018.BF4C.1)
37) Automatic Segmentation of Neurons in 3D Samples of Human Brain Cortex in JOURNAL OF THE OPTICAL SOCIETY OF AMERICA B-OPTICAL PHYSICSDi: Mazzamuto G., Costantini I., Neri M., Roffilli M., Silvestri L., Pavone F.S. Anno: 2018 38) Software tools for efficient processing of high-resolution 3D images of macroscopic brain samples in JOURNAL OF THE OPTICAL SOCIETY OF AMERICA B-OPTICAL PHYSICSDi: Mazzamuto G., Silvestri L., Costantini I., Orsini F., Roffilli M., Frasconi P., Sacconi L., Pavone F.S. Anno: 2018 39) Towards a full volumetric atlas of cell-specific neuronal spatial organization in the entire mouse brain in JOURNAL OF THE OPTICAL SOCIETY OF AMERICA B-OPTICAL PHYSICSDi: Silvestri L., Di Giovanna A.P., Mazzamuto G., Leergard T., Orsini F., Costantini I., Bjaalie J., Frasconi P., Pavone F.S. Anno: 2018 40) Whole heart cytoarchitecture at sub-cellular resolution in JOURNAL OF THE OPTICAL SOCIETY OF AMERICA B-OPTICAL PHYSICSDi: Lazzeri E., Costantini I., Cannazzaro S., Ferrantini C., Mazzamuto G., Crocini C., Cerbai E., Poggesi C., Pavone FS., Sacconi L. Anno: 2018 41) Correlative polarized light imaging and two-photon fluorescence microscopy for 3D myelinated fibers reconstruction in JOURNAL OF THE OPTICAL SOCIETY OF AMERICA B-OPTICAL PHYSICSDi: Costantini I., Menzel M., Silvestri L., Schubert N., Axer M., Amunts K., Pavone F.S. Anno: 2017 42) Fast, image-based autofocus system for high-resolution optical microscopy of whole mouse brains in JOURNAL OF THE OPTICAL SOCIETY OF AMERICA B-OPTICAL PHYSICSDi: Silvestri L., Müllenbroich M.C., Costantini I., Di Giovanna A.P., Sacconi L., Pavone F.S. Anno: 2017 ( DOI: 10.1364/BODA.2017.JTu4A.8)
43) Optimal staining and clearing protocol for whole mouse brain vasculature imaging with light-sheet microscopy in JOURNAL OF THE OPTICAL SOCIETY OF AMERICA B-OPTICAL PHYSICSDi: Di Giovanna A.P., Tibo A., Silvestri L., Muellenbroich M.C., Costantini I., Sacconi L., Frasconi P., Pavone F.S. Anno: 2017 44) Combination of two-photon fluorescence microscopy and label-free near-infrared reflectance: A new complementary approach for brain imaging in JOURNAL OF THE OPTICAL SOCIETY OF AMERICA B-OPTICAL PHYSICSDi: Costantini I., Mascaro A.L.A., Margoni E., Iannello G., Bria A., Sacconi L., Pavone F.S. Anno: 2016 ( DOI: 10.1364/CANCER.2016.JW3A.23)
45) Towards automated neuron tracing via global and local 3D image analysis in JOURNAL OF THE OPTICAL SOCIETY OF AMERICA B-OPTICAL PHYSICSDi: Acciai L., Costantini I., Pavone F.S., Conti V., Guerrini R., Soda P., Iannello G. Anno: 2016 46) A multi modal clearing method for brain imaging in JOURNAL OF THE OPTICAL SOCIETY OF AMERICA B-OPTICAL PHYSICSDi: Costantini I., Mascaro A.L.A., Di Giovanna A.P., Silvestri L., Müllenbroich M.C., Sacconi L., Pavone F.S. Anno: 2015 ( DOI: 10.1364/BRAIN.2015.BrM3B.2)
47) A new versatile clearing method for brain imaging in JOURNAL OF THE OPTICAL SOCIETY OF AMERICA B-OPTICAL PHYSICSDi: Costantini I., Di Giovanna A.P., Allegra Mascaro A.L., Silvestri L., Müllenbroich M.C., Sacconi L., Pavone F.S. Anno: 2015 ( DOI: 10.1117/12.2076908)
48) A versatile new technique to clear mouse and human brain in JOURNAL OF THE OPTICAL SOCIETY OF AMERICA B-OPTICAL PHYSICSDi: Costantini I., Di Giovanna A.P., Mascaro A.L.A., Silvestri L., Müllenbroich M.C., Sacconi L., Pavone F.S. Anno: 2015 ( DOI: 10.1117/12.2184289)
49) Brain imaging from the nano- to the macro-scale in JOURNAL OF THE OPTICAL SOCIETY OF AMERICA B-OPTICAL PHYSICSDi: Silvestri L., Allegra Mascaro A.L., Costantini I., Sacconi L., Pavone F.S. Anno: 2015 ( DOI: 10.1109/NER.2015.7146760)
50) Brain-wide charting of neuronal activation maps with cellular resolution in JOURNAL OF THE OPTICAL SOCIETY OF AMERICA B-OPTICAL PHYSICSDi: Silvestri L., Rudinskiy N., Paciscopi M., Müllenbroich M.C., Costantini I., Sacconi L., Frasconi P., Hyman B.T., Pavone F.S. Anno: 2015 ( DOI: 10.1364/BRAIN.2015.BrM3B.6)
51) Computer-based automatic identification of neurons in gigavoxel-sized 3D human brain images in JOURNAL OF THE OPTICAL SOCIETY OF AMERICA B-OPTICAL PHYSICSDi: Soda P., Acciai L., Cordelli E., Costantini I., Sacconi L., Pavone F.S., Conti V., Guerrini R., Frasconi P., Iannello G. Anno: 2015 52) Multiphoton microscopy in brain imaging in JOURNAL OF THE OPTICAL SOCIETY OF AMERICA B-OPTICAL PHYSICSDi: Allegra Mascaro A.L., Silvestri L., Costantini I., Sacconi L., Maco B., Knott G.W., Pavone F.S. Anno: 2015 ( DOI: 10.1117/12.2084183)
53) Whole brain optical imaging in JOURNAL OF THE OPTICAL SOCIETY OF AMERICA B-OPTICAL PHYSICSDi: Silvestri L., Allegra Mascaro A.L., Costantini I., Sacconi L., Pavone F.S. Anno: 2015 ( DOI: 10.1117/12.2087339)
54) Neural plasticity explored by correlative two-photon and electron/spim microscopy in JOURNAL OF THE OPTICAL SOCIETY OF AMERICA B-OPTICAL PHYSICSDi: Mascaro A.L.Allegra, Silvestri L., Costantini I., Sacconi L., Maco B., Knott G.W., Pavone F.S. Anno: 2013 ( DOI: 10.1117/12.2032505)