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Photoinitiator-free 3D scaffolds fabricated by excimer laser photocuring

  Articoli su Riviste JCR/ISI  (anno 2017)

Autori:  Farkas B., Dante S., Brandi F

Affiliazione Autori:  1 Department of Nanophysics, Istituto Italiano di Tecnologia (IIT), Via Morego 30, 16163 Genova, Italy 2 Istituto Nazionale di Ottica (INO), Consiglio Nazionale delle Ricerche (CNR), Via Moruzzi 1, 56124-Pisa, Italy

Riassunto:  Photoinitiator-free fabrication of poly(ethylene glycol) diacrylate (PEGDA) scaffolds is achieved using a novel three-dimensional (3D) printing method called mask projected excimer laser stereolithography (MPExSL). The spatial resolution of photoinitiator-free curing is suitable for 3D layer-by-layer fabrication with a single layer thickness well controllable at tens to hundreds of microns using 248 nm wavelength for the irradiation. The photoinitiator-free scaffolds are superior compared to their counterparts fabricated by using photoinitiator molecules, showing a higher level of biocompatibility. A release of toxic chemicals from the photoinitiator containing scaffolds is proven by cell proliferation tests. In contrast, no toxic release is found from the photoinitiator-free scaffolds, resulting in the very same level of cell proliferation as the control sample. The demonstration of photoinitiator-free PEGDA scaffolds enables the fabrication of 3D scaffolds with the highest level of biocompatibility for both in vitro and in vivo applications.

Rivista/Giornale:  NANOTECHNOLOGY
Volume n.:  28      Pagine da: 034001  a: -9
Parole chiave: photoinitiator-free - scaffolds - 3D printing - stereolithography - excimer laser
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